So I know you’re all expecting me to say that it was when Dad died, and yes, that was a horrible experience and first time playing the game I was genuinely crying, but no. The saddest part of the game, for me, is when the Lone Wanderer is just about to activate the purifier. My Lone Wanderer was going to be good and go in there herself, and I just wanted to speak with Dogmeat one more time. I didn’t know that there would be a special dialogue, but it said “I think it’s time for us to say goodbye, old buddy. Take care of yourself, okay?”, and Dogmeat whimpered. This really just made the game feel so real, and was definitely the saddest moment of Fallout 3 for me, because Dogmeat was my baby. Damn you, Bethesda.